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Associate Professor.
10.1002/emmm.200900020 About DOI
In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease |
| Anne N. Murphy * |
| Department of Pharmacology, MC 0636, Basic Sciences Building, Rm 3014, 9500 Gilman Dr., La Jolla, University of California, San Diego, CA 92093, USA |
| email: Anne N. Murphy (anmurphy@ucsd.edu) |
*Correspondence to Anne N. Murphy, Tel: 858-246-0573; Fax: 858-822-0041
Associate Professor.| Keywords |
| complex I PINK1 mitochondrial respiration |
| Abstract |
| For many years research in Parkinson's disease (PD) has linked mitochondrial dysfunction with the characteristic loss of dopaminergic neurons of the substantia nigra, accumulation of cytoplasmic inclusions termed Lewy bodies, and motor dysfunction (Henchcliffe & Beal, [2008]). The most compelling connection is that Parkinsonism can be observed in both humans and animals following exposure to inhibitors of complex I of the electron transport chain (Betarbet et al, [2002]). |
| Digital Object Identifier (DOI) |
10.1002/emmm.200900020 About DOI
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