EMBO Molecular Medicine

Virtual Issues

The following virtual issues are available:

To read an issue, click on the link above or choose it from the menu below.

 

Cancer
 

Despite its short existence EMBO Molecular Medicine has already attracted several high-quality submissions in the field of Cancer. Along with our monthly issues we have now decided to create a virtual issue on this topic. We will continue to update the Cancer Virtual issue as new papers in this field appear and this way, readers can easily access and appreciate the Reviews and Primary research articles we publish on the subject. Do consult the papers below. They are definitely worth it!

Awaking stem cells from dormancy: growing old and fighting cancer

Converting cancer mutations into therapeutic opportunities

Hedgehog Signaling in Colon Cancer and Stem Cells

Neurofibromatosis and lessons for the war on cancer

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

Methotrexate Induces Oxidative DNA Damage and is Selectively Lethal to Tumour Cells with Defects in the DNA Mismatch Repair Gene MSH2

Human colon cancer epithelial cells harbor active HEDGEHOG-GLI signaling that is essential for tumor growth, recurrence, metastasis and stem cell survival and expansion

Onco-miR-155 targets SHIP1 to promote TNFα-dependent growth of B cell lymphomas

Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex

Integrative genomic analyses of neurofibromatosis tumors identify SOX9 as biomarker and survival gene

Heterochromatin Protein 1α: a hallmark of cell proliferation relevant in clinical oncology


Neurodegeneration
 

Despite its short existence EMBO Molecular Medicine has already attracted several high-quality submissions in the field of Neurodegeneration. Along with our monthly issues we have now decided to create a virtual issue on this topic. We will continue to update the Neurodegeneration Virtual issue as new papers in this field appear and this way, readers can easily access and appreciate the Reviews and Primary research articles we publish on the subject. Do consult the papers below. They are definitely worth it!

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders

 

More than the sum of its parts: new mouse models for dissecting the genetic complexities of Williams-Beuren syndrome

In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease

A surrogate marker for A?42 production in the CNS

Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms

PINK1 function in health and disease

 

Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system


Celebrating stem cells
 

The EMBO Meeting 2009 in Amsterdam dedicated a special symposium to Molecular Medicine, 'The Stem Cells Molecular Medicine Symposium'. To join EMBO in its homage to the field we complemented the 'Stem Cells Molecular Medicine Symposium' with this Celebration issue. We have invited the Symposium speakers to write about their experiences and ideas in their subject(s) of interest and have worked with them to bring these to you (Clevers, 2009; Smith, 2009; Watt & Jensen, 2009;). We added a reflection by Giulio Cossu, one of our Senior Editors and a stem cell researcher himself, on the challenges the community is facing (Cossu, 2009). We will now update this Celebration Issue continuously as we are confident we will continue to publish exciting and timely articles on the topic. Enjoy your reading!

Challenges in translational research

Design principles of pluripotency

Searching for adult stem cells in the intestine

Awaking stem cells from dormancy: growing old and fighting cancer

Hedgehog signaling in colon cancer and stem cells

 

Epidermal stem cell diversity and quiescence

 

Human colon cancer epithelial cells harbor active HEDGEHOG-GLI signaling that is essential for tumor growth, recurrence, metastasis and stem cell survival and expansion

Molecular aging and rejuvenation of human muscle stem cells

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